Custom Synthesis
Tailored Solutions for Complex Chemistry Needs
Custom Synthesis of Fine and Rare Chemicals
With over 60 years of experience, Polysciences specializes in the custom synthesis of fine and hard-to-find chemicals for a variety of industries, including:
- Medical devices: Polymers, Functional Coating Materials and drug-eluting systems.
- Biopharma: Rare specialty chemicals.
- Electronics: Advanced Materials for semiconductors, PCB boards and more.
- Advanced technologies: Energetic additives and industrial applications including CMP slurries and more.
Our expertise spans biocompatible and bioresorbable polymers, specialty industrial chemicals, and advanced materials for cutting-edge technologies. With decades of innovation and industry leadership, we deliver solutions tailored to your most challenging needs.
GMP & Cleanroom Manufacturing
With Polysciences' expertise in organic chemistry, engineering, and chemical characterization, we develop and manufacture:
- Monomers, polymers, and microspheres
- Reagents to exact customer specifications
Our team ensures efficient scale-up, validation, and commercial production for materials like:
- Acrylic monomers for intraocular lenses
- EVA copolymers for drug delivery
GMP & Cleanroom Manufacturing
Analytical Capabilities
- NMR (300 MHz: 1H, 13C, 19F, 31P)
- LCMS, HPLC, GCMS
- FTIR
- GPC(5)
- DSC, TGA, TMA
- Particle Size Analysis
- Atomic Absorption
- UV/Visible & Fluorescence
- Viscosity
Chemistries
- Acrylates
- Amines
- Anhydrides
- Imides
- Glycolides
Polymerization
- Addition
- Condensation
- Free Radical
- Ring Opening
- Pressure Polymers (ethylene copolymers)
Purification Techniques
- Distillation
- Vacuum Drying
- Lyophilization
- Tangential Flow Filtration (TFF)
- Recrystalization
Reaction Capabilities
- Amidation
- Bromination
- Chiral Synthesis
- Condensation
- Dehydrohalogenation
- Diazotization
- Esterification
- Hydrogenation
- Nitration
- Oxidation
- Organometallic Synthesis
- Phosgenation
- Phosphation
- Polymerization
- Quaternizatoin
- Reductive Amination
- Sulfonation
State-of-the-Art Facilities
- 200,000 sq. ft. headquarters in Warrington, PA, with manufacturing, R&D, and cleanroom capabilities
- ISO 13485-certified and FDA-registered with ISO 5 & 8 cleanrooms
- Additional facilities in Indiana and New Jersey, with global support from sales offices in Germany, Taiwan, India, and Brazil
Synthesis and Purification Competencies
Since 1961, Polysciences has supplied specialty monomers and polymers for:
- Cardiovascular: Device coatings and biodegradable microspheres for calibration
- Ophthalmic: Specialty monomers, polymeric coatings, and additives
- Bioassay Systems: Surface-active microparticles and hydrogel polymers
Design and Manufacturing Capabilities
Monomer & Polymer Technologies
- Biodegradable polymers for controlled pharmaceutical release
- Synthetic polymers for medical coatings and excipients
- Ultra-pure monomers for ocular applications
- Hydrogels, fluorinated polymers, and pressure-sensitive polymers
- PEG-ylated molecules and block copolymers
Microsphere & Particle Technologies
- Biodegradable microspheres and nanospheres (e.g., PLGA, PEG-lactic acid)
- Functionalized particles for diagnostic assay development
- Paramagnetic microspheres for medical diagnostics
- NIST polystyrene spheres for calibration
Ready to Collaborate?
Partner with Polysciences for innovative solutions in synthesis and purification. Whether you're developing a new product or need support with your current process, our team is here to help. Click the button below to contact us and start your project today!
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